Schedule
DATE
08-Feb-22
15-Feb-22
22-Feb-22
01-Mar-22
08-Mar-22
15-Mar-22
22-Mar-22
29-Mar-22
05-Apr-22
12-Apr-22
19-Apr-22
26-Apr-22
03-May-22
10-May-22
17-May-22
24-May-22
31-May-22
07-Jun-22
14-Jun-22
Topic
AAV variants
Circuit tracing
Presynaptic inhibition
Basal Ganglia Network
Sensory Cortex
AAV variants
Engenieered virus-like particles
Targeted activation
Neuroanatomy
Spatial Sequencing
Targeting interneurons
Retrovirus
Cell profiling
Spatial Sequencing
Immune interactions
Long-term Rabies tracing
Flourescent labels
Special Lecture
SPEAKER
Mohammadsharif Tabebordbar and Kim Lagerborg, Sabeti Laboratory, Harvard University
Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species
Cell: https://www.sciencedirect.com/science/article/pii/S0092867421010023?via%3Dihub
Patrick Aldrin-Kirk, Tomas Björklund Laboratory,
"A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants"; Stem Cell Reports: https://doi.org/10.1016/j.stemcr.2021.11.014
Bryan Coptis, Michale Bruchas Laboratory, University of Washington,
"A photoswitchable GPCR-based opsin for presynaptic inhibition"
Neuron: https://doi.org/10.1016/j.neuron.2021.04.026
Nicholas N. Foster, Hong-Wei Dong Laboratory, UCLA
"The mouse cortico–basal ganglia–thalamic network "
Nature: https://www.nature.com/articles/s41586-021-03993-3.pdf
Cameron Condylis, Jerry Chen Laboratory, Boston University
"Dense functional and molecular readout of a circuit hub in sensory cortex"
Science: https://www.science.org/doi/10.1126/science.abl5981
Postponed due to illness
David Goertsen, Viviana Gradinaru Laboratory, California Institute of Technology
"AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset " Nature Neuroscience: https://www.nature.com/articles/s41593-021-00969-4.pdf
Samagya Banskota and Aditya Raguram, David Liu Laboratory, MIT
"Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins"
Cell: https://www.cell.com/action/showPdf?pii=S0092-8674%2821%2901484-7
Debora Masini, Ole Kiehn Laboratory, Copenhagen University
"Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism"
Nature Communications: https://www.nature.com/articles/s41467-022-28075-4
Gregor Schuhknecht, Kevan Martin Laboratory, Zurich University
Structure and function of a neocortical synapse
Nature: https://www.nature.com/articles/s41586-020-03134-2.pdf
Chun-Seok Cho, Jun Hee Lee Laboratory, University of Michigan
"Microscopic examination of spatial transcriptome using Seq-Scope"
Cell: https://www.sciencedirect.com/science/article/pii/S0092867421006279?via%3Dihub
Douglas Vormstein-Schneider and Jessica D. Lin, Jordane Dimidschstein Laboratory, MIT
"Viral manipulation of functionaly distinct interneurons"
Nature Neuroscience: https://www.nature.com/articles/s41593-020-0692-9
Michael Segel, Feng Zhang Laboratory, Broad Institute of MIT and Harvard
"Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery"
Science: DOI: 10.1126/science.abg6155
Lars E. Borm, Sten Linnarsson Laboratory, Karolinska Institutet
"Scalable in situ single-cell profiling by electrophoretic capture of mRNA"
BioRxiv: https://doi.org/10.1101/2022.01.12.476082
Ludvig Bergenståhle, Sci-life lab, KTH
"Super-resolved spatial transcriptomics by deep data fusion"
Nature Biotechnology: https://www.nature.com/articles/s41587-021-01075-3
Ian Clark, Cristia Gutierrez-Vazquez, Michael Wheeler,
"Barcoded viral tracing of single-cell interactions in central nervous system inflammationy"
Science: DOI: 10.1126/science.abf1230
Lei Jin, Ian Wickersham Laboratory, MIT
Long-term labeling and imaging of synaptically-connected neuronal networks in vivo using nontoxic, double-deletion-mutant rabies viruses https://www.biorxiv.org/content/10.1101/2021.12.04.471186v1
Min Yen Lee and Chenyi Mao, Joshua C Vaughan Laboratory, University of Washington
Fluorescent labeling of abundant reactive entities (FLARE) for cleared-tissue and super-resolution microscopy (Nat Pro)
Feature-rich covalent stains for super-resolution and cleared tissue fluorescence microscopy (Sci Adv)
https://www.nature.com/articles/s41596-021-00667-2 and https://www.science.org/doi/10.1126/sciadv.aba4542
Anders Björklund, Lund University:
The basal forebrain cholinergic system - its role in PD and use as a model of brain circuitry repair.