DATE

01/04/2021

08/04/2021

15/04/2021

22/04/2021

29/04/2021

05/05/2021 

13/05/2021

20/05/2021

27/05/2021

03/06/2021

10/06/2021

26/08/2021

02/09/2021

09/09/2021

16/09/2021

23/09/2021

30/09/2021

07/10/2021

14/10/2021

21/10/2021

28/10/2021

04/11/2021

11/11/2021

18/11/2021

25/11/2021

02/12/2021

09/12/2021

16/12/2021

TOPIC

Pharmacotherapy in PD

AAV-based models

Linneage tracing

aSyn species specificity

ALS

AAV Capsid development

AD: APOe4 in Astrocytes

Expansion Sequencing

Dorsal Raphe Nucleus

Enhancers

PD: Environmantal toxins

Semester Break

Single-objective light sheet microscopes

Organic dyes for live imaging

Assembloids

Flourescent reporters

Basal ganglia connectivity

Astrocytes

Genome editing:

Re-engineering Botox

Connetctivity mapping

Gene therapy

Dopamine sensors

AAV capsid development

Barcoding

AD

Machine Learning and behaviour

Nanoparticles

SPEAKER

Susane Goulding, Cork University; O'Keeffe Laboratory: 

Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and α-Synuclein-Induced Neurodegeneration.

Mol Neurobiol (2021). https://doi.org/10.1007/s12035-021-02351-8

David Marmion, Barrow Neurological; Manfredsson Laboratory: 

Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease.

Neurobiology of Disease, 2021; doi.org/10.1016/j.nbd.2020.105184

Liana Fasching, Yale University, Vaccinaro Laboratory: 

Early developmental asymmetries in cell lineage trees in living individuals.

Science, 2021; DOI: 10.1126/science.abe0981

Natalie Landeck, NIH:

Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein.

Molecular Neurodegeneration, 2020: doi.org/10.1186/s13024-020-00380-w

Sara Saez-Atienzar, NIA, Traynor laboratory:

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types.

Science Advances, 2021; DOI: 10.1126/sciadv.abd9036

Sam Sinai, Harvard University/Dyno Therapeutics:

Deep diversification of an AAV capsid protein by machine learning.

Nature Biotechnology, 2021; https://doi.org/10.1038/s41587-020-00793-4

Chao Wang, Washington University, Holtzman laboratory:

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.

Neuron, 2021: doi.org/10.1016/j.neuron.2021.03.024

Anubhav Sinha and Daniel Goodwin, MIT, Boyden Laboratory:

Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems.

Science. 2021: https://doi.org/10.1126/science.aax2656

Ryan Cho, CalTech, Gradinaru laboratory:

Dorsal Raphe Dopamine Neurons Signal Motivational Salience Dependent on Internal State, Expectation, and Behavioral Context.

Journal of Neuroscience, 2021; https://www.jneurosci.org/content/41/12/2645

John Mich, Allen Institute for Brain Science, Levi laboratory:

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

Cell Reports, 2021; https://www.sciencedirect.com/science/article/pii/S221112472100067X

Briana R De Miranda, University of Pitssburgh, Greenamyre lab:

The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease.

Neurobiology of Disease, 2021; doi: 10.1016/j.nbd.2021.105312

  

Etai Sapoznik, UT Southwestern, Fiolka Laboratory:

A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamic

eLife, 2020; https://elifesciences.org/articles/57681

Xianjun Chen, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Yang Laboratory:

Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs

Nature Biotechnology, 2019; https://www.nature.com/articles/s41587-019-0249-1

Jorge Martins, Max Dellbruk Centre for Molecular Medicine Berlin, Gouti Laboratory:

Self-Organizing 3D Human Trunk Neuromuscular Organoids

Cell Stem Cell, 2020; https://www.sciencedirect.com/science/article/pii/S1934590919305259

Changyang Linghu and Shannon L. Johnson, MIT, Boyden Laboratory

Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics

Cell, 2020; https://www.sciencedirect.com/science/article/pii/S0092867420313994

Lauren McElvain, UCD, Kleinfeld Laboratory:

Specific populations of basal ganglia output neurons target distinct brain stem areas while collateralizing throughout the diencephalon

Neuron, 2021; https://doi.org/10.1016/j.neuron.2021.03.017

Margherita Zamboni, Karolinska Institute, Frisen Laboratory:

A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury

Cell Stem Cell, 2020; https://doi.org/10.1016/j.stem.2020.07.006

Travis Blum, Broad Institute, Harvard and MIT, Liu Laboratory:

Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity

Science, 2021; https://science.sciencemag.org/content/371/6531/803

Lief Fenno, Stanford University, Deisseroth Laboratory:

Comprehensive Dual- and Triple-Feature Intersectional Single-Vector Delivery of Diverse Functional Payloads to Cells of Behaving Mammals

Neuron, 2020; https://www.sciencedirect.com/science/article/pii/S0896627320304323

John Everett, University of Pennsylvania, Sabatino Laboratory:

A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells

Nature Biotechnology, 2021; https://www.nature.com/articles/s41587-020-0741-7.pdf

Tommaso Patriachi,University of California Davis, Tan Laboratory:

An expanded palette of dopamine sensors for multiplex imaging in vivo

Nature Methods, 2020; https://doi.org/10.1038/s41592-020-0936-3

Mathieu Nonnenmacher, Voyager Therapeutics:

Rapid evolution of blood-brainbarrier-penetrating AAV capsids by RNA-driven biopanning

Molecular Therapy, 2021; https://doi.org/10.1016/j.omtm.2020.12.006

Xiaoyin Chen, Cold Spring Harbour, Zador Laboratory:

Integrating barcoded neuroanatomy with spatial transcriptional profiling enables identification of gene correlates of projections

Nature Neuroscience, 2021;

https://www.nature.com/articles/s41593-021-00842-4

Kevin Richetin, Lausanne University, Deglon Laboratory:

Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease

Nature Neuroscience, 2020; https://doi.org/10.1038/s41593-020-00728-x

Nastacia L Goodwin and Simon RO Nilsson, University of Washington, Golden Laboratory:

Simple Behavioral Analysis (SimBA) – an open source toolkit for computer classification of complex social behaviors in experimental animals

bioRxiv, 2020; https://doi.org/10.1101/2020.04.19.049452

TBA

Min Qui, Broad Institute of MIT and Harvard, Xu Laboratory:

Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

PNAS, 2021; https://www.pnas.org/content/118/10/e2020401118

Christmas special