Basal Ganglia Network
Engenieered virus-like particles
Long-term Rabies tracing
Mohammadsharif Tabebordbar and Kim Lagerborg, Sabeti Laboratory, Harvard University
Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species
Patrick Aldrin-Kirk, Tomas Björklund Laboratory,
"A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants"; Stem Cell Reports: https://doi.org/10.1016/j.stemcr.2021.11.014
Bryan Coptis, Michale Bruchas Laboratory, University of Washington,
"A photoswitchable GPCR-based opsin for presynaptic inhibition"
Nicholas N. Foster, Hong-Wei Dong Laboratory, UCLA
"The mouse cortico–basal ganglia–thalamic network "
Cameron Condylis, Jerry Chen Laboratory, Boston University
"Dense functional and molecular readout of a circuit hub in sensory cortex"
Postponed due to illness
David Goertsen, Viviana Gradinaru Laboratory, California Institute of Technology
"AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset " Nature Neuroscience: https://www.nature.com/articles/s41593-021-00969-4.pdf
Samagya Banskota and Aditya Raguram, David Liu Laboratory, MIT
"Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins"
Debora Masini, Ole Kiehn Laboratory, Copenhagen University
"Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism"
Nature Communications: https://www.nature.com/articles/s41467-022-28075-4
Gregor Schuhknecht, Kevan Martin Laboratory, Zurich University
Structure and function of a neocortical synapse
Chun-Seok Cho, Jun Hee Lee Laboratory, University of Michigan
"Microscopic examination of spatial transcriptome using Seq-Scope"
Douglas Vormstein-Schneider and Jessica D. Lin, Jordane Dimidschstein Laboratory, MIT
"Viral manipulation of functionaly distinct interneurons"
Nature Neuroscience: https://www.nature.com/articles/s41593-020-0692-9
Michael Segel, Feng Zhang Laboratory, Broad Institute of MIT and Harvard
"Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery"
Science: DOI: 10.1126/science.abg6155
Lars E. Borm, Sten Linnarsson Laboratory, Karolinska Institutet
"Scalable in situ single-cell profiling by electrophoretic capture of mRNA"
Ludvig Bergenståhle, Sci-life lab, KTH
"Super-resolved spatial transcriptomics by deep data fusion"
Nature Biotechnology: https://www.nature.com/articles/s41587-021-01075-3
"Barcoded viral tracing of single-cell interactions in central nervous system inflammationy"
Science: DOI: 10.1126/science.abf1230
Lei Jin, Ian Wickersham Laboratory, MIT
Long-term labeling and imaging of synaptically-connected neuronal networks in vivo using nontoxic, double-deletion-mutant rabies viruses https://www.biorxiv.org/content/10.1101/2021.12.04.471186v1
Min Yen Lee and Chenyi Mao, Joshua C Vaughan Laboratory, University of Washington
Fluorescent labeling of abundant reactive entities (FLARE) for cleared-tissue and super-resolution microscopy (Nat Pro)
Feature-rich covalent stains for super-resolution and cleared tissue fluorescence microscopy (Sci Adv)
Anders Björklund, Lund University:
The basal forebrain cholinergic system - its role in PD and use as a model of brain circuitry repair.