DATE

08-Feb-22

15-Feb-22

22-Feb-22 

01-Mar-22

08-Mar-22

15-Mar-22

22-Mar-22

29-Mar-22 

05-Apr-22

12-Apr-22

19-Apr-22

26-Apr-22 

03-May-22

10-May-22

17-May-22

24-May-22

31-May-22 

07-Jun-22

14-Jun-22

Topic

AAV variants

Circuit tracing

Presynaptic inhibition

Basal Ganglia Network

Sensory Cortex

AAV variants

Engenieered virus-like particles

Targeted activation

Neuroanatomy

Spatial Sequencing

Targeting interneurons

Retrovirus

Cell profiling

Spatial Sequencing

Immune interactions

Long-term Rabies tracing

Flourescent labels

Special Lecture

SPEAKER

Mohammadsharif Tabebordbar and Kim Lagerborg, Sabeti Laboratory, Harvard University

Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species

Cell: https://www.sciencedirect.com/science/article/pii/S0092867421010023?via%3Dihub

Patrick Aldrin-Kirk, Tomas Björklund Laboratory,

"A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants"; Stem Cell Reports: https://doi.org/10.1016/j.stemcr.2021.11.014

Bryan Coptis, Michale Bruchas Laboratory, University of Washington,

"A photoswitchable GPCR-based opsin for presynaptic inhibition"

Neuron: https://doi.org/10.1016/j.neuron.2021.04.026

Nicholas N. Foster, Hong-Wei Dong Laboratory, UCLA

"The mouse cortico–basal ganglia–thalamic network "

Nature: https://www.nature.com/articles/s41586-021-03993-3.pdf

Cameron Condylis, Jerry Chen Laboratory, Boston University

"Dense functional and molecular readout of a circuit hub in sensory cortex"

Science: https://www.science.org/doi/10.1126/science.abl5981

Postponed due to illness

David Goertsen, Viviana Gradinaru Laboratory, California Institute of Technology

"AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset " Nature Neuroscience: https://www.nature.com/articles/s41593-021-00969-4.pdf

Samagya Banskota and Aditya Raguram, David Liu Laboratory, MIT

"Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins"

Cell: https://www.cell.com/action/showPdf?pii=S0092-8674%2821%2901484-7

Debora Masini, Ole Kiehn Laboratory, Copenhagen University

"Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism"

Nature Communications: https://www.nature.com/articles/s41467-022-28075-4

Gregor Schuhknecht, Kevan Martin Laboratory, Zurich University

Structure and function of a neocortical synapse 

Nature: https://www.nature.com/articles/s41586-020-03134-2.pdf

Chun-Seok Cho, Jun Hee Lee Laboratory, University of Michigan

"Microscopic examination of spatial transcriptome using Seq-Scope"

Cell: https://www.sciencedirect.com/science/article/pii/S0092867421006279?via%3Dihub

Douglas Vormstein-Schneider and Jessica D. Lin, Jordane Dimidschstein Laboratory, MIT

"Viral manipulation of functionaly distinct interneurons"

Nature Neuroscience: https://www.nature.com/articles/s41593-020-0692-9

Michael Segel, Feng Zhang Laboratory, Broad Institute of MIT and Harvard

"Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery"

Science: DOI: 10.1126/science.abg6155

Lars E. Borm, Sten Linnarsson Laboratory, Karolinska Institutet

"Scalable in situ single-cell profiling by electrophoretic capture of mRNA"

BioRxiv: https://doi.org/10.1101/2022.01.12.476082

Ludvig Bergenståhle, Sci-life lab, KTH

"Super-resolved spatial transcriptomics by deep data fusion"

Nature Biotechnology: https://www.nature.com/articles/s41587-021-01075-3

Ian Clark, Cristia Gutierrez-Vazquez, Michael Wheeler, 

"Barcoded viral tracing of single-cell interactions in central nervous system inflammationy"

Science: DOI: 10.1126/science.abf1230

Lei Jin, Ian Wickersham Laboratory, MIT

Long-term labeling and imaging of synaptically-connected neuronal networks in vivo using nontoxic, double-deletion-mutant rabies viruses https://www.biorxiv.org/content/10.1101/2021.12.04.471186v1

Min Yen Lee and Chenyi Mao, Joshua C Vaughan Laboratory, University of Washington

Fluorescent labeling of abundant reactive entities (FLARE) for cleared-tissue and super-resolution microscopy (Nat Pro)

Feature-rich covalent stains for super-resolution and cleared tissue fluorescence microscopy (Sci Adv)

https://www.nature.com/articles/s41596-021-00667-2 and https://www.science.org/doi/10.1126/sciadv.aba4542

Anders Björklund, Lund University:

The basal forebrain cholinergic system - its role in PD and use as a model of brain circuitry repair.